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The Critical Assessment of Oxidative Stress Parameters as Potential Biomarkers of Carbon Monoxide Poisoning

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dc.contributor.author Hydzik, Piotr
dc.contributor.author Francik, Renata
dc.contributor.author Francik, Sławomir
dc.contributor.author Gomółka, Ewa
dc.contributor.author Eker, Ebru Derici
dc.contributor.author Krośniak, Mirosław
dc.contributor.author Noga, Maciej
dc.contributor.author Jurowski, Kamil
dc.date.accessioned 2023-11-09T13:13:38Z
dc.date.available 2023-11-09T13:13:38Z
dc.date.issued 2023
dc.identifier.citation Hydzik P, Francik R, Francik S, Gomółka E, Eker ED, Krośniak M, Noga M, Jurowski K. The Critical Assessment of Oxidative Stress Parameters as Potential Biomarkers of Carbon Monoxide Poisoning. International Journal of Molecular Sciences. 2023; 24(13):10784. https://doi.org/10.3390/ijms241310784 pl_PL
dc.identifier.issn 1661-6596
dc.identifier.uri http://195.117.226.27:8080/xmlui/handle/123456789/512
dc.description.abstract In conventional clinical toxicology practice, the blood level of carboxyhemoglobin is a biomarker of carbon monoxide (CO) poisoning but does not correspond to the complete clinical picture and the severity of the poisoning. Taking into account articles suggesting the relationship between oxidative stress parameters and CO poisoning, it seems reasonable to consider this topic more broadly, including experimental biochemical data (oxidative stress parameters) and patients poisoned with CO. This article aimed to critically assess oxidative-stress-related parameters as potential biomarkers to evaluate the severity of CO poisoning and their possible role in the decision to treat. The critically set parameters were antioxidative, including catalase, 2,2-diphenyl-1-picryl-hydrazyl, glutathione, thiol and carbonyl groups. Our preliminary studies involved patients (n = 82) admitted to the Toxicology Clinical Department of the University Hospital of Jagiellonian University Medical College (Kraków, Poland) during 2015–2020. The poisoning was diagnosed based on medical history, clinical symptoms, and carboxyhemoglobin blood level. Blood samples for carboxyhemoglobin and antioxidative parameters were collected immediately after admission to the emergency department. To evaluate the severity of the poisoning, the Pach scale was applied. The final analysis included a significant decrease in catalase activity and a reduction in glutathione level in all poisoned patients based on the severity of the Pach scale: I◦–III◦ compared to the control group. It follows from the experimental data that the poisoned patients had a significant increase in level due to thiol groups and the 2,2-diphenyl-1-picryl-hydrazyl radical, with no significant differences according to the severity of poisoning. The catalase-to-glutathione and thiol-to-glutathione ratios showed the most important differences between the poisoned patients and the control group, with a significant increase in the poisoned group. The ratios did not differentiate the severity of the poisoning. The carbonyl level was highest in the control group compared to the poisoned group but was not statistically significant. Our critical assessment shows that using oxidative-stress-related parameters to evaluate the severity of CO poisoning, the outcome, and treatment options is challenging. pl_PL
dc.language.iso en pl_PL
dc.publisher MDPI pl_PL
dc.rights Attribution 4.0 International
dc.rights.uri https://creativecommons.org/licenses/by/4.0/deed.en
dc.subject poisoning pl_PL
dc.subject carbon monoxide pl_PL
dc.subject oxidative stress pl_PL
dc.subject treatment options pl_PL
dc.title The Critical Assessment of Oxidative Stress Parameters as Potential Biomarkers of Carbon Monoxide Poisoning pl_PL
dc.type Article pl_PL


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